Akshamsaddin mentioned the microbe in his work Maddat ul-Hayat (Own book) about two centuries prior to Antonie Van
Leeuwenhoek's discovery through experimentation:
There are various types of diseases, seeds and originals as in plants and animals. ' ' We understand that the object that is causing the disease that Akşemsettin called seed here is nothing more than microbe. As a matter of fact, a closely-known French scientist Pasteur with his work on microbes, four hundred years later in his own language would describe it as a seed.
Akşemseddin (Medical scientist of the Ottoman Empire) b.1389-d.1459